Linkage mapping and genome-wide association study reveals conservative QTL and candidate genes for Fusarium rot resistance in maize.
Identifieur interne : 000051 ( Main/Exploration ); précédent : 000050; suivant : 000052Linkage mapping and genome-wide association study reveals conservative QTL and candidate genes for Fusarium rot resistance in maize.
Auteurs : Yabin Wu [République populaire de Chine] ; Zijian Zhou [République populaire de Chine] ; Chaopei Dong [République populaire de Chine] ; Jiafa Chen [République populaire de Chine] ; Junqiang Ding [République populaire de Chine] ; Xuecai Zhang [Mexique] ; Cong Mu [République populaire de Chine] ; Yuna Chen [République populaire de Chine] ; Xiaopeng Li [République populaire de Chine] ; Huimin Li [République populaire de Chine] ; Yanan Han [République populaire de Chine] ; Ruixia Wang [République populaire de Chine] ; Xiaodong Sun [République populaire de Chine] ; Jingjing Li [République populaire de Chine] ; Xiaodong Dai [République populaire de Chine] ; Weibin Song [République populaire de Chine] ; Wei Chen [République populaire de Chine] ; Jianyu Wu [République populaire de Chine]Source :
- BMC genomics [ 1471-2164 ] ; 2020.
Abstract
BACKGROUND
Fusarium ear rot (FER) caused by Fusarium verticillioides is a major disease of maize that reduces grain yield and quality globally. However, there have been few reports of major loci for FER were verified and cloned.
RESULT
To gain a comprehensive understanding of the genetic basis of natural variation in FER resistance, a recombinant inbred lines (RIL) population and one panel of inbred lines were used to map quantitative trait loci (QTL) for resistance. As a result, a total of 10 QTL were identified by linkage mapping under four environments, which were located on six chromosomes and explained 1.0-7.1% of the phenotypic variation. Epistatic mapping detected four pairs of QTL that showed significant epistasis effects, explaining 2.1-3.0% of the phenotypic variation. Additionally, 18 single nucleotide polymorphisms (SNPs) were identified across the whole genome by genome-wide association study (GWAS) under five environments. Compared linkage and association mapping revealed five common intervals located on chromosomes 3, 4, and 5 associated with FER resistance, four of which were verified in different near-isogenic lines (NILs) populations. GWAS identified three candidate genes in these consistent intervals, which belonged to the Glutaredoxin protein family, actin-depolymerizing factors (ADFs), and AMP-binding proteins. In addition, two verified FER QTL regions were found consistent with Fusarium cob rot (FCR) and Fusarium seed rot (FSR).
CONCLUSIONS
These results revealed that multi pathways were involved in FER resistance, which was a complex trait that was controlled by multiple genes with minor effects, and provided important QTL and genes, which could be used in molecular breeding for resistance.
DOI: 10.1186/s12864-020-6733-7
PubMed: 32398006
PubMed Central: PMC7218626
Affiliations:
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Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Chaopei" sort="Dong, Chaopei" uniqKey="Dong C" first="Chaopei" last="Dong">Chaopei Dong</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiafa" sort="Chen, Jiafa" uniqKey="Chen J" first="Jiafa" last="Chen">Jiafa Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Junqiang" sort="Ding, Junqiang" uniqKey="Ding J" first="Junqiang" last="Ding">Junqiang Ding</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xuecai" sort="Zhang, Xuecai" uniqKey="Zhang X" first="Xuecai" last="Zhang">Xuecai Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Global Maize Program, International Maize and Wheat Improvement Center (CIMMYT), Apdo 6-641, 06600, Mexico, DF, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Global Maize Program, International Maize and Wheat Improvement Center (CIMMYT), Apdo 6-641, 06600, Mexico, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Mu, Cong" sort="Mu, Cong" uniqKey="Mu C" first="Cong" last="Mu">Cong Mu</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yuna" sort="Chen, Yuna" uniqKey="Chen Y" first="Yuna" last="Chen">Yuna Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaopeng" sort="Li, Xiaopeng" uniqKey="Li X" first="Xiaopeng" last="Li">Xiaopeng Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Li, Huimin" sort="Li, Huimin" uniqKey="Li H" first="Huimin" 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Wang</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Xiaodong" sort="Sun, Xiaodong" uniqKey="Sun X" first="Xiaodong" last="Sun">Xiaodong Sun</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jingjing" sort="Li, Jingjing" uniqKey="Li J" first="Jingjing" last="Li">Jingjing Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Xiaodong" sort="Dai, Xiaodong" uniqKey="Dai X" first="Xiaodong" last="Dai">Xiaodong Dai</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Song, Weibin" sort="Song, Weibin" uniqKey="Song W" first="Weibin" last="Song">Weibin Song</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jianyu" sort="Wu, Jianyu" uniqKey="Wu J" first="Jianyu" last="Wu">Jianyu Wu</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China. wujianyu40@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32398006</idno><idno type="pmid">32398006</idno><idno type="doi">10.1186/s12864-020-6733-7</idno><idno type="pmc">PMC7218626</idno><idno type="wicri:Area/Main/Corpus">000060</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000060</idno><idno type="wicri:Area/Main/Curation">000060</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000060</idno><idno type="wicri:Area/Main/Exploration">000060</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Linkage mapping and genome-wide association study reveals conservative QTL and candidate genes for Fusarium rot resistance in maize.</title><author><name sortKey="Wu, Yabin" sort="Wu, Yabin" uniqKey="Wu Y" first="Yabin" last="Wu">Yabin Wu</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Zhou, Zijian" sort="Zhou, Zijian" uniqKey="Zhou Z" first="Zijian" last="Zhou">Zijian Zhou</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Dong, Chaopei" sort="Dong, Chaopei" uniqKey="Dong C" first="Chaopei" last="Dong">Chaopei Dong</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Jiafa" sort="Chen, Jiafa" uniqKey="Chen J" first="Jiafa" last="Chen">Jiafa Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Life Sciences, Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Life Sciences, Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Ding, Junqiang" sort="Ding, Junqiang" uniqKey="Ding J" first="Junqiang" last="Ding">Junqiang Ding</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Xuecai" sort="Zhang, Xuecai" uniqKey="Zhang X" first="Xuecai" last="Zhang">Xuecai Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Global Maize Program, International Maize and Wheat Improvement Center (CIMMYT), Apdo 6-641, 06600, Mexico, DF, Mexico.</nlm:affiliation><country xml:lang="fr">Mexique</country><wicri:regionArea>Global Maize Program, International Maize and Wheat Improvement Center (CIMMYT), Apdo 6-641, 06600, Mexico, DF</wicri:regionArea><wicri:noRegion>DF</wicri:noRegion></affiliation></author><author><name sortKey="Mu, Cong" sort="Mu, Cong" uniqKey="Mu C" first="Cong" last="Mu">Cong Mu</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yuna" sort="Chen, Yuna" uniqKey="Chen Y" first="Yuna" last="Chen">Yuna Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Li, Xiaopeng" sort="Li, Xiaopeng" uniqKey="Li X" first="Xiaopeng" last="Li">Xiaopeng Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Li, Huimin" sort="Li, Huimin" uniqKey="Li H" first="Huimin" last="Li">Huimin Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Han, Yanan" sort="Han, Yanan" uniqKey="Han Y" first="Yanan" last="Han">Yanan Han</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Ruixia" sort="Wang, Ruixia" uniqKey="Wang R" first="Ruixia" last="Wang">Ruixia Wang</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Xiaodong" sort="Sun, Xiaodong" uniqKey="Sun X" first="Xiaodong" last="Sun">Xiaodong Sun</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Li, Jingjing" sort="Li, Jingjing" uniqKey="Li J" first="Jingjing" last="Li">Jingjing Li</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Dai, Xiaodong" sort="Dai, Xiaodong" uniqKey="Dai X" first="Xiaodong" last="Dai">Xiaodong Dai</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Song, Weibin" sort="Song, Weibin" uniqKey="Song W" first="Weibin" last="Song">Weibin Song</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Wei" sort="Chen, Wei" uniqKey="Chen W" first="Wei" last="Chen">Wei Chen</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author><author><name sortKey="Wu, Jianyu" sort="Wu, Jianyu" uniqKey="Wu J" first="Jianyu" last="Wu">Jianyu Wu</name><affiliation wicri:level="1"><nlm:affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China. wujianyu40@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002</wicri:regionArea><wicri:noRegion>450002</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC genomics</title><idno type="eISSN">1471-2164</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b></p><p>Fusarium ear rot (FER) caused by Fusarium verticillioides is a major disease of maize that reduces grain yield and quality globally. However, there have been few reports of major loci for FER were verified and cloned.</p></div><div type="abstract" xml:lang="en"><p><b>RESULT</b></p><p>To gain a comprehensive understanding of the genetic basis of natural variation in FER resistance, a recombinant inbred lines (RIL) population and one panel of inbred lines were used to map quantitative trait loci (QTL) for resistance. As a result, a total of 10 QTL were identified by linkage mapping under four environments, which were located on six chromosomes and explained 1.0-7.1% of the phenotypic variation. Epistatic mapping detected four pairs of QTL that showed significant epistasis effects, explaining 2.1-3.0% of the phenotypic variation. Additionally, 18 single nucleotide polymorphisms (SNPs) were identified across the whole genome by genome-wide association study (GWAS) under five environments. Compared linkage and association mapping revealed five common intervals located on chromosomes 3, 4, and 5 associated with FER resistance, four of which were verified in different near-isogenic lines (NILs) populations. GWAS identified three candidate genes in these consistent intervals, which belonged to the Glutaredoxin protein family, actin-depolymerizing factors (ADFs), and AMP-binding proteins. In addition, two verified FER QTL regions were found consistent with Fusarium cob rot (FCR) and Fusarium seed rot (FSR).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>These results revealed that multi pathways were involved in FER resistance, which was a complex trait that was controlled by multiple genes with minor effects, and provided important QTL and genes, which could be used in molecular breeding for resistance.</p></div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32398006</PMID><DateRevised><Year>2020</Year><Month>05</Month><Day>22</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2164</ISSN><JournalIssue CitedMedium="Internet"><Volume>21</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>May</Month><Day>12</Day></PubDate></JournalIssue><Title>BMC genomics</Title><ISOAbbreviation>BMC Genomics</ISOAbbreviation></Journal><ArticleTitle>Linkage mapping and genome-wide association study reveals conservative QTL and candidate genes for Fusarium rot resistance in maize.</ArticleTitle><Pagination><MedlinePgn>357</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s12864-020-6733-7</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Fusarium ear rot (FER) caused by Fusarium verticillioides is a major disease of maize that reduces grain yield and quality globally. However, there have been few reports of major loci for FER were verified and cloned.</AbstractText><AbstractText Label="RESULT" NlmCategory="RESULTS">To gain a comprehensive understanding of the genetic basis of natural variation in FER resistance, a recombinant inbred lines (RIL) population and one panel of inbred lines were used to map quantitative trait loci (QTL) for resistance. As a result, a total of 10 QTL were identified by linkage mapping under four environments, which were located on six chromosomes and explained 1.0-7.1% of the phenotypic variation. Epistatic mapping detected four pairs of QTL that showed significant epistasis effects, explaining 2.1-3.0% of the phenotypic variation. Additionally, 18 single nucleotide polymorphisms (SNPs) were identified across the whole genome by genome-wide association study (GWAS) under five environments. Compared linkage and association mapping revealed five common intervals located on chromosomes 3, 4, and 5 associated with FER resistance, four of which were verified in different near-isogenic lines (NILs) populations. GWAS identified three candidate genes in these consistent intervals, which belonged to the Glutaredoxin protein family, actin-depolymerizing factors (ADFs), and AMP-binding proteins. In addition, two verified FER QTL regions were found consistent with Fusarium cob rot (FCR) and Fusarium seed rot (FSR).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results revealed that multi pathways were involved in FER resistance, which was a complex trait that was controlled by multiple genes with minor effects, and provided important QTL and genes, which could be used in molecular breeding for resistance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Yabin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Zijian</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dong</LastName><ForeName>Chaopei</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Jiafa</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Life Sciences, Synergetic Innovation Center of Henan Grain Crops and National Key Laboratory of Wheat and Maize Crop Science, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ding</LastName><ForeName>Junqiang</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Xuecai</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>Global Maize Program, International Maize and Wheat Improvement Center (CIMMYT), Apdo 6-641, 06600, Mexico, DF, Mexico.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mu</LastName><ForeName>Cong</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yuna</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiaopeng</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Huimin</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Han</LastName><ForeName>Yanan</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Ruixia</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sun</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Jingjing</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Xiaodong</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Weibin</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Wei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Jianyu</ForeName><Initials>J</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-0487-8609</Identifier><AffiliationInfo><Affiliation>College of Agronomy, Henan Agricultural University, Zhengzhou, 450002, China. wujianyu40@126.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>31761143009</GrantID><Agency>International (Regional) Joint Research Project of the National Natural Science Foundation of China</Agency><Country></Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>05</Month><Day>12</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMC Genomics</MedlineTA><NlmUniqueID>100965258</NlmUniqueID><ISSNLinking>1471-2164</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Candidate gene</Keyword><Keyword MajorTopicYN="N">Disease resistance</Keyword><Keyword MajorTopicYN="N">Ear rot</Keyword><Keyword 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uniqKey="Ding J" first="Junqiang" last="Ding">Junqiang Ding</name><name sortKey="Dong, Chaopei" sort="Dong, Chaopei" uniqKey="Dong C" first="Chaopei" last="Dong">Chaopei Dong</name><name sortKey="Han, Yanan" sort="Han, Yanan" uniqKey="Han Y" first="Yanan" last="Han">Yanan Han</name><name sortKey="Li, Huimin" sort="Li, Huimin" uniqKey="Li H" first="Huimin" last="Li">Huimin Li</name><name sortKey="Li, Jingjing" sort="Li, Jingjing" uniqKey="Li J" first="Jingjing" last="Li">Jingjing Li</name><name sortKey="Li, Xiaopeng" sort="Li, Xiaopeng" uniqKey="Li X" first="Xiaopeng" last="Li">Xiaopeng Li</name><name sortKey="Mu, Cong" sort="Mu, Cong" uniqKey="Mu C" first="Cong" last="Mu">Cong Mu</name><name sortKey="Song, Weibin" sort="Song, Weibin" uniqKey="Song W" first="Weibin" last="Song">Weibin Song</name><name sortKey="Sun, Xiaodong" sort="Sun, Xiaodong" uniqKey="Sun X" first="Xiaodong" last="Sun">Xiaodong Sun</name><name sortKey="Wang, Ruixia" sort="Wang, Ruixia" uniqKey="Wang R" first="Ruixia" last="Wang">Ruixia Wang</name><name sortKey="Wu, Jianyu" sort="Wu, Jianyu" uniqKey="Wu J" first="Jianyu" last="Wu">Jianyu Wu</name><name sortKey="Zhou, Zijian" sort="Zhou, Zijian" uniqKey="Zhou Z" first="Zijian" last="Zhou">Zijian Zhou</name></country><country name="Mexique"><noRegion><name sortKey="Zhang, Xuecai" sort="Zhang, Xuecai" uniqKey="Zhang X" first="Xuecai" last="Zhang">Xuecai Zhang</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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